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KMID : 0605720070130020275
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Journal of the Korean Society of Biological Therapies in Psychiatry
2007 Volume.13 No. 2 p.275 ~ p.282
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Blood Superoxide Dismutase Activity, Nitric Oxide and Homocysteine Concentrations in the Mild Cognitive Impairment and Alzheimer’s Dementia
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Kim ji-Eun
Jung Sung-Soo
Lee Jung-Goo
Shin Bae Seob
You Young-Sun
Youn Sung-Wook
Jeon Dong-Wook
Baek Jun-Hyung
Lee Sun-Jung
Park Sung-Woo
Kim Young-Hoon
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Abstract
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Objectives: The purpose of this study was to investigate the differences in the blood superoxide dismutase(SOD) activity, concentrations of nitric oxide(NO) and homocysteine between the normal controls, mild cognitive impairment (MCI) and Alzheimer’s dementia. And we also evaluate the correlation between blood SOD activity, concentrations of NO and homocysteine and the cognitive decline level among all subjects.
Methods: The study was carried out in 52 patients with Alzheimer’s dementia, 67 subjects with MCI and 49 normal controls. The subject received a diagnosis of Alzheimer’s dementia based on DSM-Ⅳ and NINCDS-ADRDA criteria. The Subjects were evaluated the demographic data and clinical data, including the Mini-Mental Status Examination-Korean version(MMSE-KC), clinical dementia rating scale(CDRS) and Geriatric Depression Scale (GDS-K). Plasma SOD activity, serum NO concentration and plasma homocysteine concentration were measured.
Results: There was no significant correlation between the oxidative stress, such as blood SOD activity, concentrations of NO and homocysteine in the subjects with MCI and Alzheimer’s dementia, when compared with the normal controls. There was a weak negative correlation between the total score of MMSE-KC and plasma homocysteine level (r=-0.18；p＜0.05).
Conclusion: This study concluded that the plasma homocysteine level in mild Alzheimer’s dementia could be a more useful biological marker to estimate the cognitive decline compared to blood SOD activity and NO concentration.
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KEYWORD
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Alzheimer’s dementia, Mild cognitive impairment, Superoxide dismutase, Nitric oxide, Homocysteine
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